The keyboard is a means of interacting with your computer. You really only need to use the keyboard when you're typing text. Most of the keys on the keyboard are laid out like the keys on a typewriter. But there are some special keys like Esc (Escape), Ctrl (Control), and Alt (Alternate). There are also some keys across the top of the keyboard labeled F1, F2, F3, and so forth. Those are called the function keys, and the exact role they play depends on which program you happen to be using at the moment.
Most keyboards also have a numeric keypad with the keys laid out like the keys on a typical adding machine. If you're accustomed to using an adding machine, you might want to use the numeric keypad, rather than the numbers across the top of the keyboard, to type numbers. It doesn't really matter which keys you use. The numeric keypad is just there as a convenience to people who are accustomed to adding machines.